Table 3.
Mutant Line | Treatment Type | Total Mutations * | SNVs | Indels | Total SNV/InDel Mutations | SNV/indel Mutation Frequency (bp/Event) ** | Mutation Frequency All Variants bp/Event) ** | SVs | Large Deletions | Duplications | Inversions | Insertions | Itx *** | Ctx *** | SV Frequency (bp/Event) ** |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
43,801 (control) * | None | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
43,802_control | None | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
M149 | gamma 150 Gy | 7016 | 5205 | 1432 | 6637 | 64,788.31 | 61,288.48 | 379 | 339 | 16 | 7 | 17 | 2 | 5 | 1,134,564.64 |
M153 | gamma 150 Gy | 7294 | 5054 | 1919 | 6973 | 61,666.43 | 58,952.56 | 321 | 273 | 18 | 10 | 20 | 0 | 0 | 1,339,563.86 |
M166 | gamma 300 Gy | 7147 | 3924 | 2884 | 6808 | 63,160.99 | 60,165.10 | 339 | 306 | 11 | 7 | 15 | 3 | 2 | 1,268,436.58 |
M193 | gamma 450 Gy | 8816 | 6328 | 1861 | 8189 | 52,509.46 | 48,774.95 | 627 | 558 | 38 | 13 | 18 | 9 | 30 | 685,805.42 |
M225 | X-ray 75 Gy | 6158 | 4389 | 1248 | 5637 | 76,281.71 | 69,827.87 | 521 | 460 | 26 | 16 | 19 | 10 | 42 | 825,335.89 |
M232 | X-ray 75 Gy | 9546 | 6859 | 2188 | 9047 | 47,529.57 | 45,045.05 | 499 | 445 | 30 | 14 | 10 | 10 | 45 | 861,723.45 |
M238 | X-ray 75 Gy | 8128 | 4378 | 3303 | 7681 | 55,982.29 | 52,903.54 | 447 | 406 | 14 | 13 | 14 | 4 | 51 | 961,968.68 |
M242 | X-ray 75 Gy | 18,612 | 10,619 | 7652 | 18,271 | 23,534.56 | 23,103.37 | 341 | 285 | 18 | 15 | 23 | 7 | 21 | 1,260,997.07 |
M244 | X-ray 75 Gy | 9392 | 7172 | 1984 | 9156 | 46,963.74 | 45,783.65 | 236 | 188 | 18 | 12 | 18 | 3 | 34 | 1,822,033.90 |
M314 | X-ray 150 Gy | 6271 | 4425 | 1357 | 5782 | 74,368.73 | 68,569.61 | 489 | 425 | 24 | 22 | 18 | 7 | 28 | 879,345.60 |
M317 | X-ray 150 Gy | 6069 | 4216 | 1372 | 5588 | 76,950.61 | 70,851.87 | 481 | 421 | 24 | 16 | 20 | 8 | 33 | 893,970.89 |
* Nucleotide variation identified in non-mutated control material is considered to be natural variation. Natural variants found in mutated material are removed prior to mutation counting. ** Mutation frequency calculated as (genome size = 430 Mbp)/# observed mutations. *** Translocations are also recorded as deletions from the original location. This is reflected in the total SV count.