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. 2022 Dec 4;11(23):3926. doi: 10.3390/cells11233926

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pathway enrichment analysis of modulated proteins in morphine-treated human brain endothelial cells and associated extracellular vesicles. Top five enriched pathways in both total cells and EVs upon 25, 50 and 100 μM of morphine for 24 h (|FC|> 1.2, p-value ≤ 0.05, n = 3). X-axis corresponds to −log₁₀(p-value), Y-axis corresponds to the biological pathways and the dot line represents the p-value cut-off of 0.05. HBMECs = human brain microvascular endothelial cells, EVs = extracellular vesicles.