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The role of wild-type IDH in human cells. The reaction catalyzed by IDH1 and IDH2 provides NADPH to maintain the pool of reduced glutathione and peroxiredoxin that counteract reactive oxygen species (ROS). The reaction catalyzed by IDH1 and IDH2 provides α-KG to increase the activity of the prolyl hydroxylase domain (PHD) and downregulate c-Myc expression. IDH3, the key enzyme of the TCA cycle, serves as the central regulatory site of the TCA cycle. (By Figdraw).
