Table 1.
The expression of wild-type IDHs in cancers. The expression levels of IDHs in tumors not listed in the table but mentioned in the text have not been clearly studied.
| IDH Type | Overexpressed | Downregulated |
|---|---|---|
| IDH1 | Lung adenocarcinoma [55] | Kidney cancer [56] |
| Angioimmunoblastic lymphoma [57] | ||
| Peripheral T cell lymphoma [57] | ||
| Diffuse large B cell lymphoma [57] | ||
| Glioblastoma [58] | ||
| Pancreatic ductal adenocarcinoma [59] | ||
| IDH2 | Lung cancer [60] | Kidney cancer [61] |
| Ovarian cancer [62] | Hepatocellular carcinoma [63] | |
| Breast cancer [64] | Gastric cancer [65] | |
| Endometroid carcinomas [66] | Glioblastoma [15,16] | |
| Acute lymphocytic leukemia [13] | ||
| IDH3 | Hepatocellular carcinoma [67] | |
| Glioblastoma [68] |