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Graphic illustration of LASP1 domain structure. LASP1 consists of a LIM (LIN-11, Isl-1, and MEC-3) domain (red), two F-actin binding nebulin repeats (R1 and R2) (blue), a linker site with two key regulatory phosphorylation sites (S146 and Y171) (purple), and a SH3 (Src Homology 3) domain (green). The first nebulin repeat includes a nuclear export signal (NES) between residues 71–77 (yellow). Known domain-specific protein–protein interactions are provided.
