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. 2022 Nov 29;11(23):3817. doi: 10.3390/cells11233817

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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LASP1, a Hub for Cancer Progression. LASP1 is a multifaceted protein in cancer progression and metastasis through several direct and indirect protein interactions. LASP1 binds to F-actin and is localized to actin rich protrusive structures such as invadopodia and lamellipodia, necessary for invasion and metastasis. Cancer cell viability and proliferation are promoted through activation of the PI3K/AKT signaling pathway, presumably through the LASP1 scaffolding function at the cell membrane. LASP1 plays a role in chemokine signaling by modeling CXCR4 stability, a receptor also overexpressed in several cancer entities. Nuclear LASP1 presence promotes metastasis by stabilizing Snail1 and enhancing epithelial-mesenchymal transition (EMT) and by remodeling chromatin to alter the transcriptome. Expression of mRNA is regulated by the interaction of LASP1 with Ago2, a protein of the RNA-induced silencing complex (RISC) and with eukaryotic initiation factor 4F complex (eIF4F) which induces translation of mRNA into oncoproteins. Created with BioRender software: https://biorender.com, accessed on 18 November 2022.