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Schematic diagram of photochemical controls of PROTAC. (a) The PHOTAC molecule switches between an inactive (orange) and an active form (dark green) under blue-violet light. (b) The photocaged-PROTAC is activated in a UVA-dependent manner. The photocage group is then released, enabling the degradation of POI in a controllable manner. POI: Protein of interest; Ub: Ubiquitin.
