Figure 15.

Schematic depiction of RIBOnuclease TArgeting Chimeras. The bivalent RIBOTAC molecules consist of an RNA-binding ligand (dark blue) and a ribonuclease (RNase) recruitment ligand (light blue) joined by a linker (black line). Upon binding a target RNA, RIBOTACs recruit an RNase in close proximity of the target, thereby promoting its destruction.