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. 2022 Dec 6;23(23):15440. doi: 10.3390/ijms232315440

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Summary of protein degradation target candidates involved in hallmarks of cancer. ALK: anaplastic lymphoma kinase; AR: androgen receptor; Bcl: B-cell lymphoma; BCL-xL: B-cell lymphoma-extra large; BRAF: v-raf murine sarcoma viral oncogene homolog B1; BRD: bromodomain-containing protein; BTK: Bruton’s tyrosine kinase; Cdc20: cell division cycle 20; CDK: cyclin-dependent kinase; cIAP: cellular inhibitor of apoptosis; CK2: casein kinase 2; CRABP I/II: cellular retinoic acid-binding protein 1/2; CREPT: cell cycle related and expression elevated protein in tumor; CYP1B1: cytochrome p450 family 1 subfamily B member 1; DHODH: dihydroorotate dehydrogenase; eEF2K: eukaryotic elongation factor 2 kinase; EGFR: epidermal growth factor receptor; eIF4E: eukaryotic initiating factor 4E; ER: estrogen receptor; ERK: extracellular signal-regulated kinase; FAK: focal adhesion kinase; FKBP: FK506-binding proteins; FLT3: fms-like tyrosine kinase 3; GSPT1: G1 to S phase transition 1; HDAC: histone deacetylase; HER: human epidermal growth factor receptor; HPK1: hematopoietic progenitor kinase 1; IDO1: indoleamine 2,3-dioxygenase 1; IGF-1R: insulin-like growth factor 1 receptor; IKZF: IKAROS zinc finger family; IRAK4: interleukin-1 receptor-associated kinase 4; ITK: interleukin-2-inducible T-cell kinase; JAK: janus kinase; Mcl-1: myeloid cell leukemia-1; MDM2: mouse double minute 2; MEK: mitogen-activated protein kinase kinase; PARP1: poly [ADP-ribose] polymerase 1; PDE: phosphodiesterase; PD-L1: programmed death-ligand 1; PI3K: phosphoinositide 3-kinases; PLK1: polo-like kinase 1; PRC: polycomb repressive complex; PRMT5: protein arginine methyltransferase 5; RAS: rat sarcoma; RIPK2: receptor interacting serine/threonine kinase 2; SGK3: serum/Glucocorticoid regulated kinase family member 3; SHP2: src homology 2 domain containing protein tyrosine phosphatase-2; SirT2: Sirtuin 2; SLC9A1: solute carrier family 9 member A1; STAT3: signal transducer and activator of transcription 3; TACC3: transforming acidic coiled-coil containing protein 3; TBK1: TANK-binding kinase 1; TCF: T-cell factor; TGF-β1: transforming growth factor beta 1; TRIM24: tripartite motif containing 24; TRKA/C: tropomyosin receptor kinase A/C; VEGFR: vascular endothelial growth factor receptor; α1A-AR: alpha-1A adrenergic receptor.