2H2022	Second half of the year 2022
AbTAC	Antibody-based PROTAC
AD	Atopic dermatitis
ADMET	Absorption, distribution, metabolism, excretion and toxicity
AGA	Androgenetic alopecia
AhR	Aryl hydrocarbon receptor
AID	Auxin-inducible degron
ALK	Anaplastic lymphoma kinase
AML	Acute myeloid leukemia
AR	Androgen receptor
ASGPR	Asialoglycoprotein receptor
ASO	Antisense oligonucleotide
aTAG ATP	AchillesTag Adenosine triphosphate
ATTEC	Autophagy tethering compound
AUTAC	Autophagy targeting chimera
AUTOTAC	Autophagy targeting chimera
Bcl	B-cell lymphoma
BCL-xL	B-cell lymphoma-extra large
BCR	Breakpoint cluster region protein
BET	Bromo- and extra-terminal family
BIAC	Bispecific aptamer chimera
BRAF	V-raf murine sarcoma viral oncogene homolog B1
BRD	Bromodomain-containing protein
BTK	Bruton’s tyrosine kinase
CAR	Chimeric antigen receptor
CDC20	Cell division cycle 20
CDK	Cyclin-dependent kinase
Cer	Ceritinib
cIAP	Cellular inhibitor of apoptosis
CI-M6PR	Cation-independent mannose-6-phosphonate receptor
CK1α	Casein kinase 1α
CK2	Casein kinase 2
CLIPTAC	In-cell-click-formed proteolysis targeting chimera
CLL	Chronic lymphocytic leukemia
CMA	Chaperone-mediated autophagy
CPP-LSS	Cell-penetrating peptide and lysosome-sorting sequence
CRABP I/II	Cellular retinoic acid-binding protein 1/2
CRBN	Cereblon
CREPT	Cell cycle-related and expression elevated protein in tumor
CRISPR	Clustered regularly interspaced short palindromic repeats
CT	Computed tomography
CYP1B1 DCAF5	Cytochrome p450 family 1 subfamily B member 1 DDB1 and CUL4 associated factor 5
DCAF	DDB1 and CUL4 associated factor
DHODH	Dihydroorotate dehydrogenase
DHX36	DEAH-box-protein 36
DLBCL DNA	Diffuse large B cell lymphoma Deoxyribonucleid acid
dsDNA	Double-stranded DNA
dTAG	Degrader tag
DUB	Deubiquitinating enzyme
DUBTAC	Deubiquitinase-targeting chimera
eEF2K	Eukaryotic elongation factor 2 kinase
EGFR	Epidermal growth factor receptor
eIF4E	Eukaryotic initiating factor 4E
EML4	Echinoderm microtubule-associated protein-like 4
ER	Estrogen receptor
ErbB3	Erb-b2 receptor tyrosine kinase 3
ERK	Extracellular signal-regulated kinase
ESR1	Estrogen receptor 1
EZH2	Enhancer of zeste homolog 2
FAK	Focal adhesion kinase
FDA	Food and drug administration
FEM1B	Feminization-1 homolog b
FKBP	FK506-binding proteins
FLT3	Fms-like tyrosine kinase 3
FOXO1 GlueTAC	Forkhead box protein O1 GlueBody Chimera
GNPs	Gold nanoparticles
GPD1L	Glycerol-3-phosphate dehydrogenase 1 like protein
GREB1	Growth regulating estrogen receptor binding 1
GSTP1 G4	G1 to S phase transition 1 G-quadruplex
HDAC	Histone deacetylase
HECT	Homology to E6AP C terminus
HER	Human epidermal growth factor receptor
HIF-1-alpha	Hypoxia-inducible factor 1-alpha
HIP1R	Huntingtin-interacting protein 1–related
HPK1	Hematopoietic progenitor kinase 1
HS HyT IAP	Hidradenitis suppurativa Hydrophobic tagging Inhibitors of apoptosis protein
IDO1	Indoleamine 2,3-dioxygenase 1
IGF-1R	Insulin-like growth factor 1 receptor
IKZF	IKAROS zinc finger family
IMiD	Immunomodulatory drug
IND	Investigational new drug
IRAK4	Interleukin-1 receptor-associated kinase 4
ITK IV	Interleukin-2-inducible T-cell kinase Intravenous injection
JAK	Janus kinase
JAMM	Jab1/MPN domain-associated metallopeptidase
KEAP1	Kelch-like ECH associated protein 1
LC3	Microtubule-associated protein 1A/1B-light chain 3
LD	Lipid droplets
LEF1	Lymphoid enhancer binding factor 1
LGL	Large granular lymphocyte
LHRH	Luteinizing hormone-releasing hormone
LIR	LC3-interacting region
LTR	Lysosomal targeted receptor
LYTAC	Lysosome targeting chimera
MCL	Mantle cell lymphoma
Mcl-1	Myeloid cell leukemia-1
MCPIP	Monocyte chemotactic protein-induced protein
mCRPC	Metastatic castration-resistant prostate cancer
MDM2	Mouse double minute 2
MEK	Mitogen-activated protein kinase kinase
Met	Mesenchymal epithelial transition
mHTT	Mutant huntingtin
MINDY	Motif interacting with Ub-containing novel DUB family
miR-96	MicroRNA 96
MJD	Machado–Joseph disease protein domain
MM	Multiple myeloma
MoDE-A	Molecular degrader of extracellular proteins through the ASGPR
MRI	Magnetic resonance imaging
MTH1	MutT homolog-1
MyD88	Myeloid differentiation primary response 88
NF-κB	Nuclear factor kappa-light-chain-enhancer of activated B cells
NHL	Non-Hodgkin’s lymphoma
NRAS	Neuroblastoma RAS viral oncogene homolog
NSCLC	Non-small cell lung cancer
NTRK	Neurotrophic tyrosine receptor kinase
NVOC	Nitroveratryloxycarbonyl
OTU	Ovarian tumor protease
PARP1	Poly [ADP-ribose] polymerase 1
PB1	Phox and Bem1 domain
PDE	Phosphodiesterase
PD-L1	Programmed death-ligand 1
PDX	Patient derived xenograft
PEG	Polyethylene glycol
PHOTAC	Photochemically targeting chimera
PI3K	Phosphoinositide 3-kinases
PLK1 PO	Polo-like kinase 1 Per os
POI	Protein of interest
POLY-PROTAC	Polymeric PROTAC
Pom	Pomalidomide
PR	Progesterone receptor
PRC	Polycomb repressive complex
PRMT5	Protein arginine methyltransferase 5
PROTACs	Proteolysis targeting chimeras
PTB	Phosphotyrosine-binding
PTK-7	Protein kinase-like 7
R/R	Relapsed/refractory
RAS	Rat sarcoma
RBFOX1	RNA binding Fox-1 homolog 1
RBM23	RNA binding motif protein 23
RBM39	RNA binding motif protein 39
RBP	RNA binding protein
RBR	RING-between-RING
RHAU	RNA helicase associated with AU-rich element
RIBOTAC	Ribonuclease Targeting chimera
RING	Really interesting new gene
RIPK2 RNA	Receptor interacting serine/threonine kinase 2 Ribonucleic acid
RNF	RING finger protein
RTK SC	Receptor tyrosine kinase Subcutaneous injection
SCLC	Small cell lung cancer
SERD	Selective estrogen receptor degrader
SGK	Serum/glucocorticoid regulated kinase family member
SH2	Src homology 2
SHP2	Src homology 2 domain containing protein tyrosine phosphatase-2
siRNA	Small interfering RNA
SirT2	Sirtuin 2
SLC9A1	Solute carrier family 9 member A1
SLE	Systemic lupus erythematosus
SLL	Small lymphocytic lymphoma
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily B, member 1
SNIPER	Specific and non-genetic inhibitors of apoptosis protein (IAP)-dependent protein eraser
SPAAC	Strain-promoted azide–alkyne cycloaddition
SRC-1	Steroid receptor coactivator-1
STAT3	Signal transducer and activator of transcription 3
TACC3	Transforming acidic coiled-coil containing protein 3
TBK1	TANK-binding kinase 1
TCF	T-cell factor
TCL	T-cell lymphomas
TCO	Trans-cyclooctene
TF	Transcription factor
TFF	Trefoil factor
TGF-β1	Transforming growth factor beta 1
TI	Tumor-infiltrating
TOI	Transcription factor of interest
TPD	Targeted protein degradation
TPS	Targeted protein stabilization
TRAFTAC	Transcription factor targeting Chimera
Treg	Regulatory T cell
TRIM24	Tripartite motif containing 24
TrkA	Tropomyosin receptor kinase A
TZ	Tetrazine
Ub	Ubiquitin
UCH	Ubiquitin C-terminal hydrolase
UPS	Ubiquitin-proteasome system
USP	Ubiquitin-specific protease
UV	Ultraviolet
VEGFR	Vascular endothelial growth factor receptor
VHL	Von Hippel-Lindau
WM	Waldenström macroglobulinaemia
XIAP	X-linked inhibitor of apoptosis protein
ZUFSP	Zn-finger and UFSP domain protein
α1A-AR	Alpha-1A adrenergic receptor