Table 1.
Characteristics of protein suppressive strategies. PO: per oral; IV: intravenous injection; SC: subcutaneous injection.
| Main Approaches To Suppress Target Of Interest | ||||
|---|---|---|---|---|
| PROTAC | Monoclonal Antibody | Small Molecule Inhibitor | Gene-Editing Via Nucleic Acids |
|
| Selectivity | +++ | ++ | + | ++ |
| Route Of Administration | PO/IV/SC | IV/SC | PO/IV/SC | IV/SC |
| Target Of Interest | Protein on cell surface and inside a cell | Protein on cell surface | Protein on cell surface and inside a cell | DNA or RNA |
| Metabolic Stability | ++ | -/+ | ++ | -/+ |
| Tissue/Cell Penetration | + | -/+ | ++ | -/+ |
| Concentrations Required | Substoichiometric | N/A | Stoichiometric | N/A |
| Active Binding Site | - (Can target undruggable and mutated proteins) |
+++ (Can target undruggable proteins) |
+++ (Cannot target mutated proteins) |
- (Can target undruggable proteins) |
| Inhibitory Outcome | Blockade of both enzymatic and scaffolding functions | N/A | Impaired enzymatic function | N/A |
| Elimination Of POI | +++ | - | - | +++ |
| Catalytic Mechanism Of Action | +++ | - | - | +++ |
| Systemic Delivery | +++ | +++ | +++ | - |