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Different oligomerization of ΔNp63α and TAp73 depending on p63 presence or absence. When ΔNp63α is present in cancer cells, survival will be induced. In contrast, when p63 is not present, homodimers of TAp73 will be formed and will promote pro-apoptotic gene expression (Puma and Noxa for instance). In HNSCC, both ΔNp63α and TAp73 are expressed but TID of ΔNp63α is capable of inhibiting pro-apoptotic function of the TA isoform, thus promoting survival and cancer progression.
