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Immune infiltration and signaling pathways behind RELN mutations in melanoma. (A) CIBERSORT method revealed the distinct immunocyte infiltration in RELN two subgroups. (B) Distinct enrichment scores of IFNγ signature in RELN two subgroups. Immunogenicity-related signaling pathways of (C) interferon γ response, (D) allograft rejection, and (E) interferon α response were enriched in patients with RELN mutations. * p < 0.05, ** p < 0.01.
