TABLE 1.
Life table statistics for mice pooled across all three test sites
| Group | Count | Median | % Change Median | Log‐rank | p90 | % Change p90 | Wang‐Allison |
|---|---|---|---|---|---|---|---|
| Females | |||||||
| Cont_17 | 276 | 868 | 1060 | ||||
| BD | 134 | 881 | 1 | 0.04 | 1101 | 4 | 0.16 |
| Capt | 132 | 915 | 5 | 0.002 | 1144 | 8 | 0.02 |
| Leu | 135 | 853 | −2 | 0.20 | 1109 | 5 | 0.17 |
| PB125 | 128 | 875 | 1 | 0.16 | 1094 | 3 | 0.48 |
| RaAc16 | 134 | 976 | 12 | 0.001 | 1223 | 15 | 0.001 |
| RaAc9 | 134 | 1107 | 28 | 0.001 | 1278 | 21 | 0.001 |
| Sul | 136 | 853 | ‐2 | 0.87 | 1081 | 2 | 0.30 |
| Syr | 136 | 853 | ‐2 | 0.99 | 1051 | −1 | 1.00 |
| Males | |||||||
| Cont_17 | 285 | 718 | 1029 | ||||
| BD | 145 | 785 | 9 | 0.11 | 1066 | 4 | 0.40 |
| Capt | 150 | 821 | 14 | 0.001 | 1097 | 7 | 0.01 |
| Leu | 147 | 720 | 0 | 0.27 | 1020 | −1 | 0.62 |
| PB125 | 144 | 699 | −3 | 0.64 | 1053 | 2 | 0.24 |
| RaAc16 | 138 | 815 | 14 | 0.001 | 1217 | 18 | 0.001 |
| RaAc9 | 153 | 981 | 37 | 0.001 | 1272 | 24 | 0.001 |
| Sul | 144 | 698 | −3 | 0.69 | 1037 | 1 | 0.87 |
| Syr | 152 | 763 | 6 | 0.94 | 1011 | −2 | 0.51 |
Note: p90 is 90th percentile age. Count, median, p90, and Wang/Allison calculations exclude mice removed for fighting and other causes, for which the endpoint (death or euthanasia when moribund) did not occur. Log‐rank test includes all mice entered into the study. Medians and p90 are shown in days. Percent change for median and p90 is calculated with respect to the median and p90 values for the pooled controls; they are not calculated as the mean value of site‐specific median percent changes. p‐values are not adjusted for multiple comparisons. Entries where p < 0.001 are tabulated at p = 0.001.