FIGURE 1.

Methionine restriction and cysteine restriction exert discrete effects on morphometry and plasma hormone concentrations. Eight‐week‐old male F344 rats were fed CD, SAAR, MR (MR1, MR2, MR3, MR4), and CR (CR1, CR2, CR3, CR4, CR5) diets for 12 weeks. Changes in growth rate (a), food intake (b), plasma Igf1 (c), plasma Fgf21 (d), and plasma leptin (e) were dependent on MR, while changes in plasma adiponectin (f) were dependent on CR. Two‐tailed Student's t‐test was used to find differences (represented by μ) between CD and SAAR groups (n = 16). Dose responses to MR‐ and CR‐titrated diets were analyzed by simple linear regression (coefficients represented by MR_β and CR_β; n = 8/group); error bars represent the means and standard error of means. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, n.s. = not significant. White and black triangles below the x‐axes represent the SAA gradient in MR and CR diets, respectively