Table 1.

List of inclusion and exclusion criteria.

Inclusion criteria	Exclusion criteria
18 to 60 years old, in good general health	Having a medical condition that requires premedication prior to dental visits/procedures
No known history of allergy to personal care/consumer products	Having history of allergy to common toothpaste ingredients
A minimum of 20 natural uncrowned teeth (excluding third molars)	Not enough teeth to secure the intra-oral appliance
No active unrestored cavities	Wearing orthodontic appliances
A normal salivary flow rate (stimulated and unstimulated flow of ≥ 0.7 mL/min and ≥ 0.2 mL/min, respectively)	Having an impaired salivary function or Using drugs that can affect salivary flow
Willing to give written informed consent	Having diseases of the soft or hard oral tissues
Willing to be available throughout entire study	Using antibiotics one month prior to or during this study,
Be willing to wear intra-oral appliance 24 h per day	Participating in another clinical study one week prior to the start of the washout period or during this study period
Willing to use only assigned products for oral hygiene throughout the duration of the study	Using tobacco products
	Having an advanced periodontal disease
	Having a compromised immune system (HIV, AIDS, immuno-suppressive drug therapy).