Table 1.
Effect of test compounds on phenylephrine (PE) induced contraction in aortae.
| Treatment groups | Phenylephrine (PE) induced contraction in aortae | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aortae with perivascular adipose tissue (PVAT) | Aortae without PVAT | |||||||||||||||
| Endothelium intact | Endothelium Denuded | Endothelium intact | Endothelium Denuded | |||||||||||||
| Abdominal aortae | Thoracic aortae | Abdominal aortae | Thoracic aortae | Abdominal aortae | Thoracic aortae | Abdominal aortae | Thoracic aortae | |||||||||
| Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | Emax | pEC50 | |
| Normal | 104.9 ± 3.6 | 4.6 ± 0.1 | 102.9 ± 3.9 | 5.1 ± 0.2 | 111.2 ± 5.2 | 5.5 ± 0.2 | 113.6 ± 5.7 | 5.2 ± 0.1 | 113.9 ± 3.1 | 4.9 ± 0.1 | 109.9 ± 2.3 | 5.3 ± 0.1 | 131.6 ± 1.4 | 5.5 ± 0.3 | 120.9 ± 4.7 | 5.0 ± 0.1 |
| Diabetic | 142.9 ± 3.4a | 5.9 ± 0.4 | 141.0 ± 4.1a | 5.7 ± 0.2 | 157.4 ± 6.1 | 5.9 ± 0.2 | 153.7 ± 5.2a | 5.8 ± 0.3 | 146.7 ± 4.9a | 5.5 ± 0.3 | 158.3 ± 2.3a | 5.8 ± 0.3 | 176.3 ± 5.7a | 5.9 ± 0.3 | 168.4 ± 5.5a | 6.0 ± 0.3 |
| Quercetin (diabetic) | 126.6 ± 2.0b | 5.3 ± 0.2 | 129.4 ± 4.2 | 5.5 ± 0.2 | 139.9 ± 3.8 | 5.7 ± 0.2 | 134.9 ± 4.5b | 5.6 ± 0.2 | 134.9 ± 4.5b | 5.3 ± 0.2 | 130.1 ± 3.2b | 5.6 ± 0.1 | 150.6 ± 4.4b | 5.31 ± 0.3 | 144.7 ± 5.7b | 6.1 ± 0.9 |
| Metformin (diabetic) | 126.1 ± 3.4b | 5.6 ± 0.3 | 127.6 ± 4.3 | 5.3 ± 0.2 | 130.4 ± 5.5 | 5.8 ± 0.2 | 130.8 ± 6.8b | 5.5 ± 0.2 | 132.3 ± 6.3b | 5.44 ± 0.2 | 127.4 ± 1.7b | 5.4 ± 0.2 | 142.9 ± 4.5b | 5.5 ± 0.3 | 137.1 ± 6.1b | 5.7 ± 0.2 |
| Quercetin + Metformin (diabetic) | 115.5 ± 5.0bcd | 5.1 ± 0.1 | 112.1 ± 4.0bc | 5.3 ± 0.1 | 120.5 ± 3.8 | 5.6 ± 0.2 | 122.1 ± 4.6b | 5.4 ± 0.1 | 125.1 ± 1.9b | 5.3 ± 0.1 | 119.7 ± 3.9b | 5.5 ± 0.1 | 139.9 ± 6.5bc | 5.1 ± 0.3 | 132.0 ± 6.5b | 5.9 ± 0.2 |
Data represent mean ± SEM.
The alphabet, ‘a’ shows a significant difference in comparison with normal control (p < 0.05).
The alphabet, ‘b’ shows a significant difference in comparison to diabetic control (p < 0.05).
The alphabet, ‘c’ shows a significant difference in comparison with a quercetin treatment group (p < 0.05).
The alphabet, ‘d’ shows a significant difference in comparison with the metformin treatment group (p < 0.05).