Table 2.
Effect of test compounds on acetylcholine (Ach) induced relaxation in aortae.
| Treatment groups | Acetylcholine (Ach) induced relaxation in aortae | |||||||
|---|---|---|---|---|---|---|---|---|
| Aortae with perivascular adipose tissue (PVAT) | Aortae without PVAT | |||||||
| Endothelium intact | Endothelium intact | |||||||
| Abdominal aortae | Thoracic aortae | Abdominal aortae | Thoracic aortae | |||||
| Rmax | pEC50 | Rmax | pEC50 | Rmax | pEC50 | Rmax | pEC50 | |
| Normal | 104.8 ± 4.2 | 5.2 ± 0.1 | 105.2 ± 4.4 | 5.6 ± 0.1 | 101.6 ± 0.7 | 5.4 ± 0.2 | 104.6 ± 5.0 | 5.4 ± 0.1 |
| Diabetic | 62.9 ± 4.3a | 3.4 ± 0.2 | 64.6 ± 3.0a | 3.6 ± 0.2 | 64.5 ± 4.5a | 3.5 ± 0.2 | 69.2 ± 6.2a | 3.5 ± 0.2 |
| Quercetin (diabetic) | 83.4 ± 2.5b | 4.8 ± 0.1 | 84.7 ± 2.2b | 4.8 ± 0.1 | 79.3 ± 1.2ab | 4.5 ± 0.2 | 81.2 ± 1.9ab | 4.8 ± 0.2 |
| Metformin (diabetic) | 83.0 ± 1.4b | 4.8 ± 0.1 | 87.2 ± 4.2b | 5.2 ± 0.2 | 84.4 ± 4.7ab | 4.6 ± 0.2 | 84.6 ± 2.1ab | 4.8 ± 0.1 |
| Quercetin + Metformin (diabetic) | 96.8 ± 2.2bcd | 5.0 ± 0.1 | 95.3 ± 3.8b | 5.1 ± 0.1 | 93.8 ± 2.4b | 5.1 ± 0.1 | 100.2 ± 2.6bcd | 5.2 ± 0.1 |
Data represent mean ± SEM.
The alphabet, ‘a’ shows a significant difference in comparison with normal control (p < 0.05).
The alphabet, ‘b’ shows a significant difference in comparison to diabetic control (p < 0.05).
The alphabet, ‘c’ shows a significant difference in comparison with a quercetin treatment group (p < 0.05).
The alphabet, ‘d’ shows a significant difference in comparison with the metformin treatment group (p < 0.05).