Table 3.
Effect of test compounds on sodium nitroprusside (SNP) induced relaxation in aortae.
| Treatment groups | Sodium nitroprusside (SNP) induced relaxation in aortae | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aortae with perivascular adipose tissue (PVAT) | Aortae without PVAT | |||||||||||||||
| Endothelium intact | Endothelium Denuded | Endothelium intact | Endothelium Denuded | |||||||||||||
| Abdominal aortae | Thoracic aortae | Abdominal aortae | Thoracic aortae | Abdominal aortae | Thoracic aortae | Abdominal aortae | Thoracic aortae | |||||||||
| Rmax | pEC50 | Rmax | pEC50 | Rmax | pEC50 | Rmax | pEC50 | Rmax | pEC50 | Rmax | pEC50 | Rmax | pEC50 | Rmax | pEC50 | |
| Normal | 105.9 ± 2.0 | 6.16 ± 0.1 | 103.8 ± 1.1 | 5.9 ± 0.1 | 105.5 ± 1.8 | 5.8 ± 0.1 | 105.2 ± 1.7 | 5.3 ± 0.1 | 108.2 ± 1.7 | 6.0 ± 0.2 | 108.5 ± 2.3 | 6.50 ± 0.1 | 108.5 ± 1.4 | 6.3 ± 0.1 | 112.2 ± 1.8 | 6.6 ± 0.1 |
| Diabetic | 92.6 ± 2.1 | 5.7 ± 0.2 | 92.2 ± 0.7 | 5.3 ± 0.2 | 90.1 ± 1.4 | 5.0 ± 0.1 | 91.5 ± 0.8 | 5.2 ± 0.1 | 86.2 ± 1.4 | 5.4 ± 0.19 | 92.6 ± 0.6 | 5.3 ± 0.7 | 92.2 ± 1.9 | 5.6 ± 0.3 | 93.4 ± 0.8a | 5.3 ± 0.1 |
| Quercetin (diabetic) | 94.9 ± 1.0 | 6.0 ± 0.1 | 96.4 ± 0.7 | 6.0 ± 0.1 | 99.0 ± 0.4a | 5.5 ± 0.0 | 97.6 ± 0.9 | 5.4 ± 0.1 | 97.3 ± 3.5 | 5.9 ± 0.1 | 103.7 ± 1.3 | 5.85 ± 0.1 | 97.8 ± 0.6 | 5.9 ± 0.3 | 98.7 ± 0.5 | 6.2 ± 0.1 |
| Metformin (diabetic) | 96.9 ± 0.5 | 5.9 ± 0.2 | 97.2 ± 0.7 | 5.6 ± 0.1 | 96.9 ± 0.3 | 5.6 ± 0.1 | 96.4 ± 1.0 | 5.5 ± 0.1 | 93.9 ± 1.7 | 6.0 ± 0.1 | 99.8 ± 0.8 | 6.4 ± 0.1 | 101.9 ± 1.1 | 6.3 ± 0.1 | 104.8 ± 1.0 | 6.1 ± 0.1 |
| Quercetin + Metformin (diabetic) | 99.3 ± 0.8 | 6.1 ± 0.2 | 99.7 ± 1.5 | 6.0 ± 0.1 | 103.4 ± 1.0b | 6.0 ± 0.1 | 100.7 ± 1.1 | 5.6 ± 0.2 | 98.6 ± 0.9 | 5.9 ± 0.1 | 103.0 ± 1.5 | 6.2 ± 0.1 | 103.0 ± 1.0 | 6.2 ± 0.1 | 108.4 ± 1.2 | 6.1 ± 0.1 |
Data represent mean ± SEM.
The alphabet, ‘a’ shows a significant difference in comparison with normal control (p < 0.05).
The alphabet, ‘b’ shows a significant difference in comparison to diabetic control (p < 0.05).