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. 2022 Dec 10;13:7656. doi: 10.1038/s41467-022-35417-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Schematic depicting genetic manipulations that reduce postsynaptic Ca²⁺ levels at the Drosophila NMJ. Representative electrophysiological traces are shown below each indicated genotype. B–D Quantification of average mEPSP amplitude (B), EPSP amplitude (C), and quantal content (D) values in the indicated genotypes in (A) (wild type: n = 12; GluRIIA^−/−, n = 12, p < 0.0001 for mEPSP, p = 0.607 for EPSP, p < 0.0001 for QC; GluR^Q615R: n = 12, p = 0.946 for mEPSP, p = 0.607 for EPSP, p = 0.942 for QC; G14 > PV: n = 12, p = 0.999 for mEPSP, p = 0.041 for EPSP, p = 0.437 for QC; GluRIIA^Q615R + G14 > PV: n = 13, p = 0.812 for mEPSP, p = 0.942 for EPSP, p = 0.893 for QC). Repeated measures one-way ANOVA with Dunnett’s multiple comparisons test with a significance value of 0.05. p Value adjusted for multiple comparisons. E Quantification of mEPSP and quantal content values of the indicated genotypes normalized to wild-type values (wild type: n = 12; GluRIIA^−/−, n = 12, p < 0.0001 for mEPSP, p < 0.0001 for QC; GluR^Q615R: n = 12, p = 0.946 for mEPSP, p = 0.942 for QC; G14 > PV: n = 12, p = 0.999 for mEPSP, p = 0.437 for QC; GluRIIA^Q615R + G14 > PV: n = 13, p = 0.812 for mEPSP, p = 0.893 for QC). Repeated measures One-way ANOVA with Dunnett’s multiple comparisons test with a significance value of 0.05. p Value adjusted for multiple comparisons. Error bars indicate ±SEM. Asterisks indicate statistical significance using one-way ANOVA: ****p < 0.0001; ns, not significant. n values indicate biologically independent NMJs. Absolute values for normalized data are summarized in Table S1. Source data are provided as a Source Data file.