Skip to main content
. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Hepatology. 2022 Jul 7;77(4):1164–1180. doi: 10.1002/hep.32608

Figure 5. Effects of alcohol and LDNP on FXR activity.

Figure 5.

(A) Fecal bile acid composition ratios. (B) Fecal tauro-BA/total BA ratios and selected fecal BA concentrations. (C) Serum BA composition ratios. (D) Serum tauro-BA/total BA ratios and selected serum BA concentrations. (E) Luciferase reporter assay of FXR activities of fecal extracts (left panel) and serum (right panel). Luciferase reporter assay was performed in HEK293 cells transfected with FXR expression plasmid, FXR reporter plasmid, and β-galactosidase expression plasmid. Cells were stimulated with CDCA (20 μM) alone, fecal supernatant or serum for 6 hours. n = 3–5/group.