FIG. 1.

In situ killing of 4 × 10⁹ CFU of bacteria per kg by 20 mg of imipenem per kg (●), each administered concomitantly and by separate i.p. injections to CF-1 mice. The bacterial count was determined following peritoneal lavage. Data obtained when saline vehicle was injected in place of antibiotic are also shown (○). (Top) E. coli O111:B4; (bottom) S. aureus M. Three mice were used per datum point. Conditions of bacterial growth are as described in Materials and Methods.