Box 2 | Expert opinion on functional imaging

• FDG-PET is useful for monitoring progression from prodromal dementia to dementia and for the differential diagnosis of AD

• In resource-constrained settings, FDG-PET would be useful in supporting the diagnosis of AD-type dementia, even though it lacks specificity

• Amyloid-PET is useful for confirming amyloid pathology in MCI and mild dementia, for the differential diagnosis of dementia, and in the detection of AD in young (≤65 years old) patients

• Tau-PET is useful in the differential diagnosis of dementia, as well as to track and predict disease progression

• The expert group predicts that the use of amyloid-PET and tau imaging may be more widespread with the advent of disease-modifying therapies in AD

AD, Alzheimer’s disease; FDG-PET, fluorodeoxyglucose positron emission tomography; MCI, mild cognitive impairment