Table 4.

Quality of the evidence-GRADE

Outcome measures	Number of included studies	Aspect 1: limitations in risk of bias	Aspect 2: inconsistency	Aspect 3: indirectness	Aspect 4: imprecision	Aspect 5: publication bias	Quality of the evidence (GRADE)
BV/TV	12 [35–52]	− 1a	0	− 1b	− 1c	0	Very low
BMD	6 [37, 43, 44, 47, 50, 52]	− 1a	0	− 1b	− 1c	0	Very low
Tb.N	4 [35, 39, 41, 46]	− 1a	0	− 1b	− 1c	0	Very low
Tb.Sp	4 [39, 41, 46, 50]	− 1a	0	− 1b	− 1c	0	Very low
Tb.Th	4 [39, 41, 46, 50]	− 1a	0	− 1b	− 1c	0	Very low

^aLack of randomization and blinding

^bDifferences in animal models and interventions

^cHigh heterogeneity