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. 2022 Dec 10;20:521. doi: 10.1186/s12951-022-01736-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Cellular uptake and therapeutic efficacy of Fe-PHCN@DOX nano-nuclear-reactors. A Confocal images of the CT26 subcellular localization of the Fe-PHCN@DOX with/without HA treatment. The scale bar represents 50 μm. B Fluorescence images of DCF-stained CT26 cells under different group treatment. The scale bar represents 50 μm. C Intracellular GSH depletion under different concentrations of Fe-PHCN@DOX. D Cell survival rate after different group treatment by the CCK-8 assay. E, F Cell cycle arrest in G2 phase was measured under different group treatment. G Fluorescence images of calcein AM (green, live cells) and PI (red, dead cells) costained CT26 cells after different group treatment. The scale bar represents 100 μm. H Flow cytometry analysis of apoptosis in CT26 cells treated with different groups. The p values were analyzed using the Log-rank (Mantel-Cox) test. Data are presented as the mean ± standard error of the mean. *p < 0.05, **p < 0.01, ***p < 0.001