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. 2022 Dec 7;17:6113–6129. doi: 10.2147/IJN.S390378

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© 2022 Wu et al.

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The structure and content of EVs. EVs have a complex composition of nucleic acids (DNA, RNA), protein, metabolites and amino acid.⁷ Some proteins are on the surface of the particles and used as markers for EVs, such as CD9, CD63, CD81.^1–3 Additionally, EVs surface also include cell adhesion proteins, cell‐type‐specific proteins, and lipid.^4–9 Created with BioRender.com.