Table 3.
Grade Analysis for Certainty of Evidence for association between SLDH and PMDs
| No of studies | Design | Certainty of evidence | No of participants | Effect | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SLDH among PMDs and Healthy controls | ||||||||||
| Risk of Bias | Inconsistency | Indirectness | Imprecision | Other considerations | PMDs | Healthy controls | Mean Difference (Relative 95% CI) | Certainty | ||
| 12 | Observational studies (Case control) | Not serious | Not serious | Not serious | Not serious | Strong association | 281 | 255 | 199.57 (95.84-30.30) | |
| MODERATE | ||||||||||
| SLDH among OSMF and Healthy controls | ||||||||||
| 5 | Observational studies (Case control) | Not serious | Not serious | Not serious | Not serious | Strong association | 145 | 140 | 2.57 (2.16-2.98) | |
| MODERATE | ||||||||||
CI, Confidence interval; OR, Odds ratio