Jakobsen et al.
Criteria	Yes	No	Other (CD, NR, NA)*
1. Was the study described as randomized, a randomized trial, a randomized clinical trial, or an RCT?	☑
2. Was the method of randomization adequate (i.e., use of randomly generated assignment)?	☑
3. Was the treatment allocation concealed (so that assignments could not be predicted)?	☑
4. Were study participants and providers blinded to treatment group assignment?	☑
5. Were the people assessing the outcomes blinded to the participants’ group assignments?		☑
6. Were the groups similar at baseline on important characteristics that could affect outcomes (e.g., demographics, risk factors, and comorbid conditions)?	☑
7. Was the overall dropout rate from the study at endpoint 20% or lower of the number allocated to treatment?	☑
8. Was the differential drop-out rate (between treatment groups) at endpoint 15 percentage points or lower?		☑
9. Was there high adherence to the intervention protocols for each treatment group?	☑
10. Were other interventions avoided or similar in the groups (e.g., similar background treatments)?			☑
11. Were outcomes assessed using valid and reliable measures, implemented consistently across all study participants?	☑
12. Did the authors report that the sample size was sufficiently large to be able to detect a difference in the main outcome between groups with at least 80% power?		☑
13. Were outcomes reported or subgroups analyzed pre-specified (i.e., identified before analyses were conducted)?		☑
14. Were all randomized participants analyzed in the group to which they were originally assigned, that is, did they use an intention-to-treat analysis?	☑

^*CD: Cannot determine, NA: Not applicable, NR: Not reported