Table 2:

Number of patients randomized to receive BUP-NX and methadone that were observed as following a given strategy: (1) increased dose under the strategy and were observed as increasing dose, or (0) had a constant dose under the strategy and were observed as having a constant dose.

	Wk. 2	3	4	5	6	7	8	9	10	11
Constant dose strategy, d4
BUP-NX
d1a	375	269	227	125	115	107	112	89	75	78
d2b	316	258	235	200	192	191	174	162	161	155
d3c	557	444	396	295	281	269	255	230	220	214
Total	1028	1109	947	928	801	779	748	710	675	647
Methadone
d1a	88	93	115	46	50	45	41	37	40	31
d2b	158	186	221	168	168	164	145	139	125	118
d3c	160	187	229	176	176	173	154	150	139	129
Total	182	223	253	270	220	216	205	211	198	189
Increase dose in response to use strategy, d1
BUP-NX
Increase	147	59	40	24	11	6	7	4	4	3
Constant	605	702	685	698	661	652	614	602	589	560
Total	752	761	725	722	672	658	621	606	593	563
Methadone
Increase	216	133	83	64	16	16	13	12	12	14
Constant	72	100	128	157	158	165	157	169	154	153
Total	288	233	211	221	174	181	170	181	166	167
Increase dose if under threshold strategy, d2
BUP-NX
Increase	67	26	21	13	9	3	6	3	3	4
Constant	695	770	696	699	597	584	561	536	510	490
Total	762	796	717	712	606	587	567	539	513	494
Methadone
Increase	312	200	122	89	43	33	30	18	20	14
Constant	2	5	22	34	41	45	52	64	69	64
Total	314	205	144	123	84	78	82	82	89	78
Hybrid dosing strategy, d3
BUP-NX
Increase	182	72	55	34	18	9	12	7	6	6
Constant	423	511	513	527	492	488	465	457	443	424
Total	605	583	568	561	510	497	477	464	449	430
Methadone
Increase	325	215	136	106	51	38	35	22	27	24
Constant	0	4	12	23	31	35	42	53	54	52
Total	325	219	148	129	82	73	77	75	81	76

^aNo. of dose increases that would have been indicated applying d1

^bNo. of dose increases that would have been indicated applying d2

^cNo. of dose increases that would have been indicated applying d3