FIGURE 6.

Immune response of tumor microenvironment after combinatorial Onco^Ad and PD‐1 mAb therapy in the CT26 mouse model. (A) Organ toxicity was assessed through H&E staining of samples of the liver, spleen, lung, hearts, kidneys, and brain (n = 3, *p < 0.05 and **p < 0.01). Magnification 10×. (B–E) Biochemical analysis after combinatorial treatment with Onco^Ad and PD‐1 mAb in CRC mouse model. Quantification ALT, AST, CREA, and UREA are presented. (F) Schematic mechanism of combinatorial treatment with Onco^Ad and PD‐1 mAb therapy in the CRC mouse model.