TABLE 3.

Postdischarge Clinical Outcomes by Number of Medications at Discharge

	No. Patients With Event and Cumulative 1-y Incidence, %	Crude HR	95% CI	P	Adjusted HR	95% CI	P
All-cause death or any rehospitalization
Quartile 1 (≤5)	146 (30.8)	Reference			Reference
Quartile 2 (6–8)	268 (31.6)	1.01	0.84–1.21	.85	0.89	0.73–1.09	.46
Quartile 3 (9–11)	289 (39.7)	1.36	1.13–1.62	.0008	1.09	0.89–1.33	.26
Quartile 4 (≥12)	251 (50.3)	1.81	1.50–2.18	<.0001	1.30	1.04–1.61	.01
All-cause death
Quartile 1 (≤5)	39 (8.3)	Reference			Reference
Quartile 2 (6–8)	82 (9.7)	1.22	0.89–1.68	.21	1.10	0.78–1.56	.55
Quartile 3 (9–11)	82 (11.3)	1.43	1.04–1.97	.03	1.21	0.85–1.74	.28
Quartile 4 (≥12)	66 (13.3)	1.72	1.23–2.40	.001	1.30	0.88–1.92	.18
Cardiovascular death
Quartile 1 (≤5)	22 (4.7)	Reference			Reference
Quartile 2 (6–8)	53 (6.3)	1.02	0.91–1.15	.62	1.02	0.90–1.17	.66
Quartile 3 (9–11)	49 (6.9)	1.06	0.97–1.20	.29	1.06	0.93–1.22	.21
Quartile 4 (≥12)	38 (7.9)	1.16	1.02–1.33	.02	1.10	0.94–1.29	.22
Any rehospitalization
Quartile 1 (≤5)	136 (28.9)	Reference			Reference
Quartile 2 (6–8)	242 (29.0)	0.98	0.82–1.20	.98	0.87	0.71–1.08	.23
Quartile 3 (9–11)	264 (36.9)	1.33	1.10–1.61	.002	1.07	0.86–1.32	.53
Quartile 4 (≥12)	230 (46.9)	1.81	1.49–2.20	<.0001	1.29	1.02–1.63	.03
Rehospitalization for HF
Quartile 1 (≤5)	70 (15.1)	Reference			Reference
Quartile 2 (6–8)	142 (17.2)	1.18	0.90–1.54	.22	1.03	0.76–1.37	.88
Quartile 3 (9–11)	171 (24.2)	1.79	1.38–2.31	<.0001	1.37	1.03–1.84	.03
Quartile 4 (≥12)	151 (31.2)	2.29	1.76–2.99	<.0001	1.50	1.10–2.05	.009

Abbreviations: CI, confidence interval; HF, heart failure; HR, hazard ratio.