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. 2022 Dec 12;22:929. doi: 10.1186/s12879-022-07896-0

Table 5.

The association of TCZ and SAR with DILI

Drugs N ROR PRR IC EBGM
(95% two-sided CI) (χ2) IC025 EBGM05
TCZ 191 1.33 (1.14, 1.55) 1.3 (13.27) 0.36 (0.31) 1.28 (1.13)
SAR 83 12.94 (9.6, 17.44)* 7.31 (468.91)* 2.83 (2.1)* 7.11 (5.54)*

TCZ-associated DILI ROR=1.33, 95% two-sided CI(1.14,1.55), PRR=1.3, χ2=13.27, EBGM=1.28, 95% one-sided CI=1.2; SAR-associated DILI ROR=12.94, 95% two-sided CI(9.6,17.44), PRR=7.31, χ2=468.91, EBGM=7.11, 95% one-sided CI=5.54; * means a strong signal that represents a strong statistical association between the drug and the adverse reaction