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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Hypertension. 2022 Oct 31;80(1):160–168. doi: 10.1161/HYPERTENSIONAHA.122.20217

Table 2.

Mediation effect parameters in separate models with a single mediator and with adult cIMT as the outcome

Predictor Mediator c β1 β2 βInd c’ Mediation
effect (%)
Childhood BMI Adult SBP 0.138 (0.025)* 0.080 (0.025)* 0.166 (0.027)* 0.013
[0.005, 0.025]* 		0.125
[0.066, 0.185]* 		9.4
[2.2, 16.6]*
Adult LDLC 0.138 (0.025)* 0.004 (0.027) 0.110 (0.025)* 0.000
[−0.007, 0.008]		 0.137
[0.079, 0.198]* 		0.0
[−5.1, 5.8]
 Adult AIP  0.138 (0.025)* 0.106 (0.025)* 0.101 (0.027)* 0.011
[0.005, 0.019]* 		0.127
[0.068, 0.189]* 		8.0
[2.0, 13.9]*
Adult Glucose 0.138 (0.025)* 0.094 (0.026)* 0.096 (0.025)* 0.009
[0.003, 0.018]* 		0.129
[0.068, 0.193]* 		6.5
[0.7, 12.3]*
Adult BMI Adult SBP 0.111 (0.025)* 0.185 (0.025)* 0.161 (0.027)* 0.030
[0.016, 0.048]* 		0.081
[0.017, 0.156]* 		27.0
[11.7, 42.3]*
Adult LDLC 0.111 (0.025)* 0.095 (0.027)* 0.102 (0.025)* 0.010
[0.003, 0.020]* 		0.101
[0.040, 0.169]* 		9.0
[1.5, 16.5]*
Adult AIP 0.111 (0.025)* 0.299 (0.024)* 0.089 (0.028)* 0.027
[0.010, 0.045]* 		0.084
[0.018, 0.156]* 		24.3
[8.7, 40.0]*
Adult Glucose 0.111 (0.025)* 0.264 (0.026)* 0.088 (0.027)* 0.023
[0.007, 0.041]* 		0.088
[0.027, 0.158]* 		20.7
[5.5, 35.9]*
BMI AUC Adult SBP 0.150 (0.025)* 0.166 (0.024)* 0.154 (0.027)* 0.026
[0.013, 0.041]* 		0.125
[0.062, 0.197]* 		17.3
[8.0, 26.6]*
Adult LDLC 0.150 (0.025)* 0.037 (0.027) 0.105 (0.025)* 0.004
[−0.002, 0.012]		 0.146 [0.086, 0.216]* 2.7
[−2.5, 7.8]
Adult AIP 0.150 (0.025)* 0.222 (0.024)* 0.084 (0.027)* 0.019
[0.006, 0.033]* 		0.132 [0.068, 0.203]* 12.7
[3.7, 21.6]*
Adult Glucose 0.150 (0.025)* 0.270 (0.025)* 0.074 (0.027)* 0.020
[0.004, 0.039]* 		0.130 [0.069, 0.201]* 13.3
[2.4, 24.3]*

c, β1, and β2 are standardized regression coefficients (standardized errors). βInd and c’ are standardized regression coefficients [95% confidence intervals]. Mediation effects are percentages [95% confidence intervals].

c=total effect; c’=direct effect; β1=indirect effect 1; β2=indirect effect 2; βInd=indirect effect (β1 × β2)

*

, P < 0.05 for being different from 0

cIMT=carotid intima-media thickness; BMI=body mass index; SBP=systolic blood pressure; LDLC=low-density lipoprotein cholesterol; AIP=atherogenic index of plasma; AUC=area under the curve