Table 2:
Description of parameters, their R variable name, base-case values and distribution.
| Parameter | R name | Base-case | Distribution |
|---|---|---|---|
| Number of cycles (nT) | n_cycles | 75 years | - |
| Names of health states (n) | v_names_states | H, S1, S2, D | - |
| Annual discount rate for costs | d_c | 3% | - |
| Annual discount rate for QALYs | d_e | 3% | - |
| Number of PSA samples (K) | n_sim | 1,000 | - |
| Annual constant transition rates | |||
| - Disease onset (H to S1) | r_HS1 | 0.150 | gamma(30, 200) |
| - Recovery (S1 to H) | r_S1H | 0.500 | gamma(60, 120) |
| - Disease progression (S1 to S2) | r_S1S2 | 0.105 | gamma(84, 800) |
| Annual mortality | |||
| - Background mortality rate (H to D) | r_HD | 0.002 | gamma(20, 10000) |
| - Hazard ratio of death in S1 vs H | hr_S1 | 3.0 | lognormal(log(3.0), 0.01) |
| - Hazard ratio of death in S2 vs H | hr_S2 | 10.0 | lognormal(log(10.0), 0.02) |
| Annual costs | |||
| - Healthy individuals | c_H | $2,000 | gamma(100.0, 20.0) |
| - Sick individuals in S1 | c_S1 | $4,000 | gamma(177.8, 22.5) |
| - Sick individuals in S2 | c_S2 | $15,000 | gamma(225.0, 66.7) |
| - Dead individuals | c_D | $0 | - |
| Utility weights | |||
| - Healthy individuals | u_H | 1.00 | beta(200, 3) |
| - Sick individuals in S1 | u_S1 | 0.75 | beta(130, 45) |
| - Sick individuals in S2 | u_S2 | 0.50 | beta(230, 230) |
| - Dead individuals | u_D | 0.00 | - |
| Treatment A cost and effectiveness | |||
| - Cost of treatment A, additional to state-specific health care costs | c_trtA | $12,000 | gamma(73.5, 163.3) |
| - Utility for treated individuals in S1 | u_trtA | 0.95 | beta(300, 15) |
| Treatment B cost and effectiveness | |||
| - Cost of treatment B, additional to state-specific health care costs | c_trtB | $12,000 | gamma(86.2, 150.8) |
| - Reduction in rate of disease progression (S1 to S2) as hazard ratio (HR) | hr_S1S2_trtB | log(0.6) | lognormal(log(0.6), 0.02) |