. Author manuscript; available in PMC: 2023 Dec 5.

Published in final edited form as: ChemMedChem. 2022 Oct 13;17(23):e202200408. doi: 10.1002/cmdc.202200408

Table 3.

Anti-proliferative activity of difluoromethoxy-substituted estratriene derivatives against various cancer cell lines from the NCI-60 cell line panel.^[a]

Cpd	Lung HOP-62	Colon HCT-116	CNS SF-539	Melan-oma UACC-62	Ovarian OVCAR-3	Renal SN12C	MGM

10	1.98	0.474	0.266	0.564	0.527	0.567	0.661
11	0.648	0.375	0.427	0.460	0.383	1.22	0.813
12	0.634	0.406	0.313	0.498	0.386	0.692	0.646

^[a]

Results are GI₅₀ values in μM and the mean of three determinations. The MGM represents the mean concentration that caused 50% growth inhibition in all 60 cell lines.