Table 5.

Steroid sulfatase inhibition of difluoromethoxy-substituted estratriene sulfamate derivatives in JEG-3 human choriocarcinoma assays in vitro.^[a]

Cpd	R1	R2	R3, R4	Cell lysate	Whole cells
4	SO2NH2	OCH3	H, OSO2NH2	99	4.2
10	SO2NH2	OCF2H	H, OSO2NH2	44	3.7
11	H	OCF2H	H, OSO2NH2	>5000	N.D.
12	SO2NH2	OCF2H	H, OH	75	18.6
16	SO2NH2	OCF2H	=O	56	5.6
23	SO2NH2	CF2H	=O	19	0.055
25	SO2NH2	H	=O	79	0.118

^[a]Results are IC₅₀ values in nM and are the mean of three determinations. N.D. not determined.