. Author manuscript; available in PMC: 2024 Jan 1.

Published in final edited form as: Pediatr Infect Dis J. 2022 Oct 3;42(1):27–31. doi: 10.1097/INF.0000000000003726

Table 3.

Simulated Metronidazole Exposure Parameters

Parameter	Infants with Seizure, N=31	Infants without Seizure, N=1,515	p-value

C_max (ng/mL)
All doses	9.4 (8.0, 11.4)	9.8 (8.6, 11.1)	0.002
Bolus doses	17.4 (16.4, 19.9)	18.7 (16.6, 20.3)	0.24
Maintenance doses	9.4 (8.0, 11.4)	9.7 (8.6, 10.9)	<0.001

C_min (ng/mL)
All doses	4.6 (3.4, 7.4)	5.7 (3.5, 6.2)	<0.001
Bolus doses	8.5 (6.4, 11.3)	7.1 (6.4, 11.4)	0.24
Maintenance doses	4.4 (3.4, 6.1)	5.7 (3.4, 6.2)	<0.001

AUC_ss (ng*hr /mL)	221.9 (196.4, 431.8)	217.0 (208.0, 250.3)	0.008

AUC_c (ng*hr /mL)	3923.6 (1846.5, 7293.8)	2445.5 (1327.1, 4140.7)	0.10

AUC_c, cumulative area under the curve; AUC_ss, area under the plasma concentration–time curve at steady state; C_min, minimum concentration; hr, hour; mL, milliliter; ng, nanogram