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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2022 Sep 3;192(1-2):13–27. doi: 10.1002/ajmg.b.32920

Figure 1.

Figure 1.

Matrix plot of correlations between epigenetic variables and chronological age in brain and blood tissues. Cells with a significant correlation (p-value <0.05) are colored according to their correlation coefficient for epigenetic variable-chronological age correlation, with green and pink indicating a negative and a positive correlation, respectively. The correlation coefficient is indicated in the number within each cell. Abbreviations: Substance use disorder (SUD); Alcohol use disorder (AUD); Stimulant use disorder (StUD); Opioid use disorder (OUD); DNAmAge-based epigenetic age acceleration (AAR); Extrinsic epigenetic age acceleration (EEAA); Intrinsic epigenetic age acceleration (IEAA); Hannum-based epigenetic age acceleration (AAHannum); GrimAge-based epigenetic age acceleration (AAGrim); PhenoAge-based epigenetic age acceleration (AAPheno).