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. 2022 Nov 28;9:1008410. doi: 10.3389/fcvm.2022.1008410

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Copyright © 2022 Konrath, Mailer, Beerens, Englert, Frye, Kuta, Preston, Maas, Butler, Roest, de Laat and Renné.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TG in mouse whole blood initiated by various contact activators. Citrate-anticoagulated venous whole blood collected from wild-type mice was supplemented in serial dilutions with (A–E) kaolin from 0.4 to 50.0 μg/ml, (F–J) ellagic acid from 0.008 to 1.0 μg/ml, and (K–O) synthetic polyP (polymer size: ≥400 mers) from 0.08 to 10.0 μg/ml in buffer. (A–C) Representative real-time TG graphs of n = 3 independent experiments measured in triplicates each and calculated endogenous thrombin potential [ETP; (B,G,L)], lag times (C,H,M), maximal thrombin [peak height; (D,I,N)] and time to maximal thrombin [time to peak; (E,J,O)] are shown. Each condition was measured in triplicates. Bars represent mean ± SD. One-way ANOVA followed by Dunnett's multiple comparisons test was performed to assess statistical significance. P > 0.05 (ns, not significant), P < 0.05 (*), P < 0.01 (**).