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. Author manuscript; available in PMC: 2023 Jun 5.
Published in final edited form as: Nat Genet. 2022 Dec 5;54(12):1865–1880. doi: 10.1038/s41588-022-01205-w

Extended Data Fig. 4. H3.1K27M, ACVR1-mutant pontine gliomas arise from an NKX6-1+ ventral brainstem progenitor.

Extended Data Fig. 4

a. Volcano plot of differentially expressed genes between H3.3K27M pons and H3.3K27M thalamus HGG. HOX genes are indicated in purple. Only genes with mean normalized expression > 100 are included.

b. Epigenomic state at NKX6-1 and PAX3 in representative H3.3K27M pons HGG primary tumors and cell lines. For scATACseq data, each track represents RPKM-normalized aggregated accessibility for one malignant single-cell population.

c. Co-expression of NKX6-1 and PAX3 in bulk RNAseq data for pons HGG with each K27M histone variant.