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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Sex Transm Dis. 2022 Sep 30;50(1):42–44. doi: 10.1097/OLQ.0000000000001717

Figure 1.

Figure 1.

Age-adjusted serum neurofilament light chain (NfL) concentrations in uncomplicated syphilis (Uncx Syph); and in asymptomatic neurosyphilis (Asx NS) and symptomatic neurosyphilis (Sx NS) pre-therapy (pre) and post-therapy (post). The gray dotted line represents the highest adjusted serum NfL concentration in individuals with uncomplicated syphilis. One of 10 individuals with asymptomatic neurosyphilis and three of 10 with symptomatic neurosyphilis had adjusted serum NfL concentrations above the highest value in individuals with uncomplicated syphilis. Additionally, one individual with asymptomatic neurosyphilis had an almost doubling of their serum concentration 14 months after appropriate treatment in the setting of possible treatment failure.