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. Author manuscript; available in PMC: 2023 Dec 6.
Published in final edited form as: Cell Metab. 2022 Oct 19;34(12):1977–1998.e9. doi: 10.1016/j.cmet.2022.09.026

Figure 6. Shared and unique injury responses of renal tubular epithelial cells.

Figure 6.

(A-B) UMAP plots of cells of LoH (A) and DCT, CNT and PC (B) in subclustering analysis. Abbreviations of cell types have been described in Figure 1D.

(C-D) Dot plots showing expression of genes specific to cell clusters identified in Figure 6A–B. Visualization was performed on dataset combining both uni-IRI and UUO subsets.

(E) Connected bar plots displaying the proportional abundance of healthy and injured TECs (including TAL, DCT and CNT) in each group condition, which identifies a shared injury response of TECs in an insult-dependent manner.

(F) Heat maps presenting expression of genes that are either co-varied across all injured TECs or dysregulated in a cell-type-specific manner compared to the healthy state of each TEC.