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. Author manuscript; available in PMC: 2023 Dec 6.
Published in final edited form as: Cell Metab. 2022 Oct 14;34(12):1932–1946.e7. doi: 10.1016/j.cmet.2022.09.019

Figure 5. Auranofin lowers serum leptin levels in obese wild-type mice.

Figure 5.

(A) Fed serum adiponectin, (B) leptin and (C) corresponding leptin to adiponectin ratio for WT+HFD (n=8-12/group). (D) eWAT Lep in wild-type mice treated with vehicle or auranofin on HFD (n=4/group). RNA-Seq data shown as reads per kb million (RPKM). (E) The hypothalamus was stained and quantified for p-STAT3 (n=4/group) within the dorsal medial hypothalamus (DMH), ventral medial hypothalamus (VMH) and arcuate (ARC) nuclei of HFD mice treated with auranofin (1 mg/kg), scale=200 μm.

All data are mean ± SEM. *p<0.05 by unpaired t-test (A-D) and two-way ANOVA with Tukey’s multiple comparisons test (E)