Figure 5.

Succinate exacerbates experimental murine necrotizing enterocolitis. Data are from four independent experiments. (A) Percent survival in the four groups. Log-rank test P value: *P < 0.05. (B) Body weight changes in mouse pups in the four groups. Baseline differences in weight were not significant. Two-way ANOVA multiple-comparison method P value: *P < 0.05. (C) Representative morphological observations of intestinal tissue of each group immediately following excision at the time of the experimental endpoint. (D) Representative photomicrographs of terminal ileal sections from each of the four groups. Magnification ×100; scale bars:100 μm. (E) Histological scoring of intestinal regions observed in the control, NEC, Lsuc and Hsuc groups. Kruskal – Wallis test P value: *P <0.05, **P <0.01.