Table 1.
Demographic and clinical characteristics of patients with Non-CVD and CVD.
| Group | Non-CVD (n = 428) | CVD (n = 138) | Total (n = 566) |
|---|---|---|---|
| Age (years) | 47.3 ± 11.7 | 59.5 ± 10.1 | 50.3 ± 12.5 |
| Sex (male, %) | 260.0 (60.7) | 101.0 (73.2) | 361.0 (63.8) |
| BMI(kg/m2) | 25.2 (23.2, 27.1) | 25.4 (23.4, 27.2) | 25.3 (23.2, 27.1) |
| Smoking, n (%) | 152.0 (34.3) | 72.0 (52.2) | 224.0 (39.6) |
| Hypertension, n (%) | 144.0 (33.6) | 80.0 (58.0) | 250.0 (44.2) |
| SBP (mmHg) | 135.4 ± 16.7 | 141.3 ± 19.1 | 135.0 (125.0, 147.0) |
| FBG (mmol/L) | 9.5 (7.9, 11.7) | 9.8 (7.9, 12.4) | 9.5 (7.9, 11.9) |
| PBG (mmol/L) | 14.5 (11.7, 17.1) | 14.9 ± 4.1 | 14.6 (11.7, 17.1) |
| HbA1c (%) | 10.8 (9.0, 12.3) | 10.6 ± 2.6 | 10.7 (8.9, 12.4) |
| FCP (ng/ml) | 1.6 (1.1, 2.3) | 1.9 (1.3, 2.5) | 1.7 (1.2, 2.4) |
| WBC (10^9g/L) | 6.2 (5.4, 7.4) | 6.7 (5.7, 8.1) | 6.4 (5.5, 7.6) |
| Hb (g/L) | 143.0 (134.0, 152.3) | 141.2 (132.0, 149.3) | 143 (133, 152) |
| NLR | 1.6 (1.2, 2.0) | 1.6 (1.3, 2.1) | 1.6 (1.2, 2.0) |
| FIB (g/L) | 2.4 (2.2, 2.9) | 2.7 (2.2, 3.0) | 2.5 (2.2, 2.9) |
| D-dimer (ug/L) | 130.0 (100.0, 250.0) | 160.0 (100.0, 282.5) | 140.0 (100.0, 260.0) |
| ALT (U/L) | 25.0 (18.0, 43.0) | 27.0 (17.0, 43.0) | 26.0 (18.0, 43.0) |
| AST (U/L) | 16.0 (12.0, 23) | 15.0 (12.0, 22.0) | 16.0 (12.0, 23.0) |
| ALB (g/L) | 37.9 (35.4, 40.2) | 36.4 (34.5, 39.2) | 37.4 (35.0, 39.9) |
| Bicarbonate (mmol/L) | 23.7 (22.2, 25.6) | 24.3 ± 2.7 | 23.9 (22.2, 25.7) |
| BUN (mmol/L) | 4.7 (3.8, 5.7) | 5.5 (4.2, 6.5) | 4.8 (3.9, 5.9) |
| SC r (µmol/L) | 69.2 ± 18.2 | 74.5 ± 16.6 | 70.5 ± 15.7 |
| UA (µmol/L) | 262.8 (211.2, 320.3) | 289.5 ± 85.6 | 269.8 (216.8, 325.6) |
| CysC (mmol/L) | 0.7 (0.6, 0.9) | 0.7 (0.6, 0.9) | 0.7 (0.6, 0.9) |
| eGFR (ml/min/1.73 min) | 109.5 (91.1, 132.6) | 96.1 (79.0, 112.3) | 104.8 (88.5, 129.2) |
| K (mmol/L) | 4.3 (4.1, 4.5) | 4.2 ± 0.4 | 4.3 (4.0, 4.5) |
| Ca (mmol/L) | 2.4 (2.3, 2.4) | 2.3 (2.3, 2.4) | 2.4 (2.3, 2.4) |
| P (mmol/L) | 1.2 (1.1, 1.3) | 1.2 ± 0.2 | 1.2 (1.1, 1.3) |
| TC (mmol/L) | 4.8 (4.1, 5.5) | 4.8 (4.3, 5.5) | 4.8 (4.2, 5.5) |
| TG (mmol/L) | 2.5 (1.7, 3.7) | 2.9 (2.0, 4.2) | 2.6 (1.8, 3.8) |
| HDL (mmol/L) | 1.0 (0.9, 1.2) | 0.9 (0.8, 1.1) | 1.0 (0.9, 1.1) |
| LDL (mmol/L) | 2.3 (1.9, 2.8) | 2.4 (2.0, 2.8) | 2.3 (1.9, 2.8) |
| Apoa1 (g/L) | 1.2 (1.1, 1.3) | 1.2 (1.1, 1.3) | 1.2 (1.1, 1.3) |
| Apob (g/L) | 1.0 (0.9, 1.2) | 1.1 (0.9, 1.3) | 1.0 (0.9, 1.2) |
| UACR (mg/g) | 9.9 (6.7, 16.7) | 10.0 (6.7, 18.4) | 10.0 (6.7, 16.9) |
| TyG index | 9.8 (9.4, 10.3) | 10.1 (9.7, 10.4) | 9.9 (9.5, 10.3) |
| TC/HDL | 4.9 (3.9, 5.9) | 5.1 (4.3, 6.2) | 4.9 (4.0, 5.9) |
| TSH (uIU/ml) | 2.0 (1.3, 2.9) | 2.0 (1.3, 2.6) | 2.0 (1.3, 2.8) |
| fT3 (pmol/L) | 4.3 (3.9, 4.7) | 4.2 ± 0.7 | 4.3 (3.8, 4.7) |
| fT4 (pmol/L) | 16.6 (15.0, 18.3) | 16.5 ± 2.2 | 16.6 (14.9, 18.3) |
| QRSKI3 | 7.5 (3.2, 14.4) | 23.8 (16.6, 32.6) | 10.6 (4.3, 19.5) |
| QRSIK3 (<10%), n (%) | 262.0 (61.2) | 12.0 (8.7) | 274.0 (48.4) |
| QRSIK3 (10%-20%), n (%) | 128.0 (29.9) | 35.0 (25.4) | 163.0 (28.8) |
| QRSIK3 (> 20%), n (%) | 38.0 (8.9) | 91.0 (65.9) | 129.0 (22.8) |
| FRS | 9.7 (4.7, 18.4) | 25.3 (15.6, 30.0) | 13.3 (5.6, 21.6) |
| FRS (<10%), n (%) | 214.0 (50.0) | 15.0 (10.9) | 229.0 (40.5) |
| FRS (10%-20%), n (%) | 129.0 (30.1) | 41.0 (29.7) | 170.0 (30.0) |
| FRS (> 20%), n (%) | 85.0 (19.9) | 82.0 (59.4) | 167.0 (29.5) |
The eGFR is calculated according to the CKD-EPI formula. CVD, cardiovascular disease; BMI, body mass index; SBP, systolic blood pressure; FBG, fasting blood glucose; PBG, postprandial blood glucose; HbA1c, haemoglobin A1c; FCP, fasting c- peptide; WBC, white blood cell; Hb, haemoglobin; NLR, neutrophil to lymphocyte ratio; FIB, fibrinogen; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, serum albumin; BUN, blood urea nitrogen; SCr, serum creatinine; UA, uric acid; CysC, cystatin C; eGFR, estimated glomerular filtration rate; TC, total cholesterol; TG, triglycerides; HDL, high density lipoprotein; LDL, low density lipoprotein; Apoa1, apolipoprotein a1; Apob, apolipoprotein b; UACR, urine albumin-to-creatinine ratio; TyG index, triglyceride-glucose index; TSH, thyroid stimulating hormone; fT3, free triiodothyronine; fT4, free thyroxine; QRISK3, QRESEARCH risk estimator version 3; FRS, framingham risk score.