Table 2.
Cox regression analysis of CVD- related risk factors.
| Variables | β-coefficient | HR (95% CI) | P value |
|---|---|---|---|
| Age | 0.087 | 1.190 (1.074, 1.108) | <0.001* |
| Sex (female) | 0.524 | 1.689 (1.159, 2.463) | 0.006* |
| BMI | 0.018 | 1.018 (0.968, 1.070) | 0.492 |
| Smoking | 0.856 | 2.374 (1.692, 3.330) | <0.001* |
| Hypertension | 1.52 | 4.571 (3.113, 6.711) | <0.001* |
| SBP | 0.018 | 1.019 (1.009, 1.028) | <0.001* |
| FBG | 0.056 | 1.057 (0.997, 1.121) | 0.062 |
| PBG | 0.022 | 1.023 (0.981, 1.067) | 0.297 |
| HbA1c | -0.023 | 0.977 (0.910, 1.049) | 0.521 |
| FCP | 0.181 | 1.198 (1.018, 1.410) | 0.029* |
| WBC | 0.155 | 1.168 (1.067, 1.278) | 0.001* |
| Hb | -0.003 | 0.997 (0.987, 1.006) | 0.484 |
| NLR | -0.001 | 0.999 (0.988, 1.010) | 0.857 |
| FIB | 0.209 | 1.232 (1.037, 1.456) | 0.018* |
| ALT | -0.004 | 0.996 (0.989, 1.002) | 0.206 |
| AST | -0.009 | 0.991 (0.976, 1.005) | 0.204 |
| ALB | -0.073 | 0.930 (0.894, 0.968) | <0.001* |
| Bicarbonate | 0.004 | 1.045 (0.987, 1.107) | 0.132 |
| BUN | 0.123 | 1.131 (1.065, 1.201) | <0.001* |
| SC r | 0.018 | 1.019 (1.008, 1.029) | 0.001* |
| UA | 0.002 | 1.002 (1.000, 1.004) | 0.032* |
| CysC | 0.299 | 1.349 (0.677, 2.687) | 0.394 |
| eGFR | -0.015 | 0.985 (0.979, 0.991) | <0.001* |
| K | -0.254 | 0.776 (0.546, 1.102) | 0.157 |
| Ca | -0.993 | 0.370 (0.170, 1.279) | 0.116 |
| P | -0.535 | 0.586 (0.241, 1.423) | 0.238 |
| TC | 0.044 | 1.045 (0.913, 1.196) | 0.524 |
| TG | 0.029 | 1.030 (0.976, 1.086) | 0.284 |
| HDL | -0.71 | 0.492 (0.240, 1.008) | 0.053 |
| LDL | 0.062 | 1.064 (0.839, 1.350) | 0.608 |
| Apoa1 | 0.428 | 1.534 (0.624, 3.773) | 0.352 |
| Apob | 0.356 | 1.428 (0.964, 2.115) | 0.076 |
| UACR | 0.002 | 1.002 (0.998, 1.006) | 0.392 |
| TyG Index | 0.277 | 1.320 (1.049, 1.659) | 0.018* |
| TC/HDL | 0.105 | 1.111 (1.014, 1.216) | 0.023* |
| TSH | 0.001 | 1.001 (0.901, 1.112) | 0.99 |
| fT3 | -0.113 | 0.875 (0.723, 1.060) | 0.172 |
| fT4 | -0.04 | 0.961 (0.903, 1.024) | 0.217 |
| QRISK3 (Grade) | 1.787 | 5.972 (4.565, 7.813) | <0.001* |
| FRS (Grade) | 1.17 | 3.223 (2.535, 4.097) | <0.001* |
CVD, cardiovascular disease; BMI, body mass index; SBP, systolic blood pressure; FBG, fasting blood glucose; PBG, postprandial blood glucose; HbA1c, haemoglobin A1c; FCP, fasting c-peptide; WBC, white blood cell; Hb, haemoglobin; NLR, neutrophil to lymphocyte ratio; FIB, fibrinogen; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, serum albumin; BUN, blood urea nitrogen; SCr, serum creatinine; UA, uric acid; CysC, cystatin C; eGFR, estimated glomerular filtration rate; TC, total cholesterol; TG, triglycerides; HDL, high density lipoprotein; LDL, low density lipoprotein; Apoa1, apolipoprotein a1; Apob, apolipoprotein b; UACR, urine albumin-to-creatinine ratio; TyG index, triglyceride-glucose index; TSH, thyroid stimulating hormone; fT3, free triiodothyronine; fT4, free thyroxine; QRISK3, QRESEARCH risk estimator version 3; FRS, framingham risk score.