Table 5.

Sensitivity, specificity, PPV, NPV and C-statistics of QRISK3 and FRS (patients with loss to follow-up were classified as the non-CVD group).

Tools	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	C-statistics (95% CI)
QRISK3†	54.7	91.3	96.7	30.5	0.730 (0.690, 0.770)
FRS†	43.5	89.1	94.8	25.6	0.663 (0.619, 0.708)
QRISK3††	86.1	65.9	92.1	50.8	0.760 (0.711, 0.810)
FRS††	76.3	59.4	89.6	35.3	0.679 (0.627, 0.731)

†Dichotomised risk scores using a cut-off of 10% 10-year CVD. †† Dichotomised risk scores using a cut- off of 20% 10-year CVD. PPV, positive predictive value; NPV, negative predictive value; C-statistics, concordance statistics; QRISK3, QRESEARCH risk estimator version 3; FRS, framingham risk score.