Table 2:

Inclusion and exclusion criteria.

Inclusion	Exclusion
Documented informed consent	Extraperitoneal metastatic disease
Age ≥ 18 years	Progression on both first- and second-line systemic chemotherapy; progression on irinotecan-based chemotherapy
Histologically confirmed appendiceal or colorectal carcinoma	Bowel obstruction requiring nasogastric or gastrostomy tube
No contraindications for laparoscopy	Life expectancy of less than 6 months
Visible peritoneal disease on cross sectional imaging or on laparoscopy	Ascites due to liver cirrhosis or portal vein thrombosis
At least 4 months of standard of care systemic chemotherapy (e.g. FOLFOX, FOLFIRI, FOLFOXIRI). If irinotecan-based chemotherapy was used the patients should not have progression on irinotecan-based chemotherapy	Simultaneous tumor-debulking with gastrointestinal resection
	Uncontrolled current cardiac or renal comorbidity, myelosuppression, or hepatic impairment
	Exclusive total parenteral nutrition