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. 2022 Nov 28;12:888570. doi: 10.3389/fonc.2022.888570

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Copyright © 2022 Zhong, Yao, Liu, Zhang, Zhang, Zhang, Lin, Li, Li, Jiang, Cheng, Xu, Wen, Yang, Zhang, Cheng, Huang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of TME characteristics associated with ferroptosis-related phenotypes. (A, B) Differences in pathway signatures related to tumor development and the infiltration level of MDSCs in the TME of ferroptosis-related molecular pattern and genomic subtype groups in the GEO cohort. (C–F) Differences in TIDE scores of ferroptosis-related molecular pattern and genomic subtype groups in the TCGA cohort. (G–I) Differences in gene signatures related to tumor development in the TME of ferroptosis-related molecular pattern and genomic subtype groups in the GEO cohort, G: Immune checkpoint-related genes, H: cytokines related to inflammation associated with AML, I: cell adhesion molecules associated with AML. Kruskal–Wallis test, *P < 0.05; **P < 0.01; ***P < 0.001.