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. 2022 Nov 28;12:888570. doi: 10.3389/fonc.2022.888570

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Copyright © 2022 Zhong, Yao, Liu, Zhang, Zhang, Zhang, Lin, Li, Li, Jiang, Cheng, Xu, Wen, Yang, Zhang, Cheng, Huang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis TME characteristics associated with ferroptosis-related phenotypes. (A, B) GO annotation and KEGG pathway enrichment analysis showed the functions of the ferroptosis-related phenotype signature genes. (C) PPI network of ferroptosis-related phenotype signature genes. (D–G) Differences in the FSscore of ferroptosis-related molecular patterns and genomic subtypes in GEO and TCGA groups, Kruskal–Wallis test. (D–I) Differences in the survival of patients in high and low FSscore groups in the GEO and TCGA cohorts, (H): GEO group, (I): TCGA group, log rank test. (J, K) The ROC curves showed the specificity and sensitivity of the FSscore; (J): GEO group, (K): TCGA group.